Extracellular annexins in hemostasis system
نویسندگان
چکیده
منابع مشابه
Extracellular matrix proteins in hemostasis and thrombosis.
The adhesion and aggregation of platelets during hemostasis and thrombosis represents one of the best-understood examples of cell-matrix adhesion. Platelets are exposed to a wide variety of extracellular matrix (ECM) proteins once blood vessels are damaged and basement membranes and interstitial ECM are exposed. Platelet adhesion to these ECM proteins involves ECM receptors familiar in other co...
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Myoblast fusion into multinucleated myotubes is a crucial step in skeletal muscle development and regeneration. Here, we accumulated murine myoblasts at the ready-to-fuse stage by blocking formation of early fusion intermediates with lysophosphatidylcholine. Lifting the block allowed us to explore a largely synchronized fusion. We found that initial merger of two cell membranes detected as lipi...
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The sarcolemma of smooth muscle cells is composed of alternating stiff actin-binding, and flexible caveolar domains. In addition to these stable macrodomains, the plasma membrane contains dynamic glycosphingolipid- and cholesterol-enriched microdomains, which act as sorting posts for specific proteins and are involved in membrane trafficking and signal transduction. We demonstrate that these li...
متن کاملFungal annexins: a mini review.
The large family of annexins is composed of more than a thousand members which are typically phospholipid-binding proteins. Annexins act in a number of signalling networks and membrane trafficking events which are fundamental to cell physiology. Annexins exert their functions mainly through their calcium-dependent membrane binding abilities; however, some calcium-independent interactions have b...
متن کاملAnnexins - their role in cartilage mineralization.
Annexins II, V and VI are highly expressed by hypertrophic and terminally differentiated growth plate chondrocytes and by osteoblasts. Because of the localization of annexins in areas of cartilage and bone mineralization, we hypothesized that these annexins play a regulatory role in the mineralization process. In this article we review the function of annexins II, V and VI in physiological mine...
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ژورنال
عنوان ژورنال: Biopolymers and Cell
سال: 2016
ISSN: 0233-7657,1993-6842
DOI: 10.7124/bc.000911